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Explanation of How Chromosomal Abnormalities Result In Miscarriage
Miscarriage and Recurrent Miscarriage
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The study mentioned below looked at egg formation and the arrangement of chromosomes. It isnt a perfect process and getting the right number of chromosomes almost seems like a "hit and miss" process. Read more:
During meiosis, fibres called microtubules attach themselves to the centre (kinetochore) of the chromosomes. The microtubules act like fishing lines and once a chromosome is caught it is pulled to the opposite side of the cell from its partner.
But, before the microtubules hook the chromosomes, the researchers noticed that they herd them together into the centre of the cell. Despite this repositioning, almost 90 per cent of chromosomes were let off the hook only to be re-caught.
See Also: Miscarriage Over 40 (www.getpregnantover40.com)
"We saw that they [the microtubules] have to go through several tries before getting the connection right," says Ellenberg.
Third time lucky
In fact, some chromosomes were released up to six times, though most averaged three. Ellenberg says this means that the pathway that corrects the errors by uncoupling the chromosome and the microtubule is therefore heavily used and thus more prone to making mistakes — resulting in too few or too many chromosomes in the egg.
"Our findings provide a plausible explanation for the high rate of errors during egg formation."
Ellenberg adds that their observations make error correction proteins good candidates for age-related infertility.
"They form the basis to focus our future work on age-related female infertility, as it seems very likely that a component of the pathway that corrects these errors will be involved. The individual proteins that make up the machinery to correct the errors may simply not have a sufficiently long life-span to function well in very old oocytes," he says.
From: www.cbc.ca
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